The results indicated significant association between positive/high cyclin B1 expression and Size of tumor (OR 0.60, 95% CI 0.38, 0.93; P = 0.02) and Distant metastasis (OR 0.30, 95% CI 0.13, 0.71; P = 0.006), using fixed-effect models. This evidence concerns the gene CCNB1 and neoplasm.