To determine the effect of IDH mutation on DNA methylation and RNA expression, we did a differential analysis between 10 IDH-mutated and 23 IDH wild-type astrocytic tumors, and 28,609 DNA methylation probes, 1,862 genes, 42 miRNAs and 1,734 lncRNAs were identified differentially expressed in total. This evidence concerns the gene IDH1 and astrocytic tumor.