Although the present study does not throughtly explore the relationship between the immune context and RANK expression by nasopharyngeal carcinoma, we consider safe to assume that the already known links between RANK/RANKL pathway and Treg in neoplastic context can be extended also to nasopharyngeal pathology, given the established role of Treg in NPC tumorogenesis and progression [24–26] and our newly highlighted connection between NPC and RANK. The gene discussed is TNFSF11; the disease is nasopharyngeal carcinoma.