Of them, PARK7 [19], IQGAP1 [20], SPATS2L and RRM2 [21], SQSTM1(p62) [22], AKR1C1 [23], KRT8 [24], ANXA7 [25], NQO1[26], SERPINA1[27], GLS [28] ANXA3 [29, 30], ACSL3 [31], and the tumor suppressor UCHL1 [32] are known to be associated with HCC initiation, progression, metastasis, and drug resistance. This evidence concerns the gene RRM2 and hepatocellular carcinoma.