As a newly characterized tumor suppressor gene, UNC5D was recently reported to be mutated in non-small-cell lung cancer, uterine cancer and stomach cancer in a public dataset from The Cancer Genome Atlas (TCGA); however, the TCGA analysis of PTC implied that somatic mutations targeting UNC5D are uncommon in PTC, which was consistent with data from the Catalogue of Somatic Mutations in Cancer (COSMIC) database. The gene discussed is UNC5D; the disease is non-small cell lung carcinoma.