We further examined METTL3 expression by qRT-PCR in three RCC cell lines (CAKI-1, CAKI-2 and ACHN) and a normal human renal tubular epithelial cell line HK-2, which demonstrated that METTL3 was also lower expressed in RCC cell lines than in HK-2 (Figure 3C). The gene discussed is METTL3; the disease is renal cell carcinoma.