CASP8 and hepatocellular carcinoma: A robust activation of caspase-3/7 by Diphyllin methyl ether in other cell lines was similarly reported by Won et al, in human hepatoma cells [27] but other caspases have been reported to be activated in response to Diphyllin methyl ether treatment such as caspase-8 in human hepatoma Hep 3B and Hep G2 cells [11].