TRPM8 and glioblastoma: As a result, a single dose of 2 Gy increased TRPM8 activity in T98G cells and 10 Gy total dose applied in 5 fractions stimulated TRPM8 abundance in T98G and U251 cells in vitro and in an orthotopic glioblastoma mouse model in vivo (Supplementary Figure 2) pointing to a radiation-induced upregulation of TRPM8 function in human glioblastoma.