TRPM8 and glioblastoma: First, we confirmed expression of TRPM8 and further TRP channels in glioblastoma by querying the glioblastoma multiforme database of The-Cancer-Genome-Atlas (TCGA), and by analyzing protein expression in primary spheroid cultures of human glioblastoma specimens and mRNA expression in human glioblastoma cell lines (Supplementary Figure 1).