In the present study, TRPM8 mRNA abundance increased significantly in T98G and U251 glioblastoma cells and not quite significantly in U-87MG cells during fractionated radiation (see Supplementary Figure 2C-2F) Similarly, fractionated radiation increased TRPM8 immunofluorescence in an orthotopic U-87MG-Katushka glioblastoma mouse model in vivo (see Supplementary Figure 2G). Here, TRPM8 is linked to glioblastoma.