Aberrantly expressed TRPM8 channels have been proposed to contribute to epithelial-mesenchymal-transition and metastasis of breast cancer [4], growth and metastasis of pancreatic adenocarcinoma [5], adaptation to hypoxia of prostate cancer [6], metastasis and chemotherapy resistance of osteosarcoma [7], poor prognosis of urothelial carcinoma [8], carcinogenesis of colon carcinoma [9], and migration of glioblastoma cells [10, 11]. The gene discussed is TRPM8; the disease is breast cancer.