First, we confirmed expression of TRPM8 and further TRP channels in glioblastoma by querying the glioblastoma multiforme database of The-Cancer-Genome-Atlas (TCGA), and by analyzing protein expression in primary spheroid cultures of human glioblastoma specimens and mRNA expression in human glioblastoma cell lines (Supplementary Figure 1). Here, TRPM8 is linked to cancer.