Therefore, we determined the effect of the synthetic TRPM8 super-agonist icilin (3-(2-Hydroxyphenyl)-6-(3-nitrophenyl)-3,4-dihydropyrimidin-2(1H)-one) on the BK K+ channel activity in the plasma membrane of T98G glioblastoma cells by patch-clamp on-cell (cell-attached) recording. This evidence concerns the gene TRPM8 and glioblastoma.