Nevertheless, this previous study [2] demonstrated that among 20 TRP channels subtypes of the melastatin (TRPM), vanilloid (TRPV), and canonical (TRPC) family tested, TRPM8 showed highest upregulation in glioblastoma as compared to normal brain tissue strongly suggesting a pivotal function of TRPM8 in gliomagenesis. The gene discussed is TRPM8; the disease is glioblastoma.