TJP1 and type 1 diabetes mellitus: D-4F treatment in T1DM-stroke rats significantly decreases BBB leakage (n=4/group, *p<0.05, Figure 1b) and significantly increases tight junction protein ZO-1 (Zone occluden-1) expression around blood vessels in the ischemic border zone at 48 hours after stroke compared to phosphate buffered saline (PBS) treated T1DM stroke rats (n=8/group, *p<0.05, Figure 1c).