Previous studies have demonstrated that MIM-B can activate the EGFR pathway in Drosophila oocyte border cell migration and endocytosis [41], and another work reported that MIM-B not only promoted EGFR expression in early stage HNSCC cells/tumors but also inhibited EGFR signaling at high cell densities [20, 42]. Here, MTSS1 is linked to head and neck squamous cell carcinoma.