Recently, Cufi and colleagues demonstrated that IFN type I overexpression together with activation of TLR3-mediated pathways are present in thymomas from MG patients; such findings suggest that MG might develop after a pathogen infection in thymoma patients with a genetic susceptible background [18], as it has been postulated for MG associated with thymic hyperplasia. Here, TLR3 is linked to thymoma.