The 20 patients (male:female, 11:9) had features typical of MYCN-amplified stage 2 (n=2) or stage 3 (n=18) HR-NB, including young age (10-75 [median 25] months), abdominal site, predominance of unfavorable histology, and elevated serum levels of lactate dehydrogenase at diagnosis (Table 1). The gene discussed is MYCN; the disease is neuroblastoma.