In that report, the “overall poor prognosis” led the authors to note that “[f]urther studies are warranted to determine if myeloablative consolidation followed by 13-cis-RA maintenance therapy statistically significantly improves outcome.” Similarly, ASCT did not improve survival in the INRG cohort of MYCN-amplified stage 2 NB (n=39, including nine ASCT), with 5-year EFS/OS of 57%/67% [13]. This evidence concerns the gene MYCN and neuroblastoma.