Reportedly, parafibromin expression was down-regulated during gastric, colorectal and head and neck carcinogenesis, and inversely linked to such aggressive behaviors as tumor size, depth of invasion, lymphatic invasion, lymph node metastasis or TNM staging by inducing apoptosis and cell cycle arrest, and suppressing proliferation, migration, invasion, and epithelial-mesenchymal transition [13, 15, 18]. This evidence concerns the gene CDC73 and neoplasm.