FLT3 and acute myeloid leukemia: In multivariate analysis including known risk factors (age, WBC, NPM1mut/noFLT3-ITD genotype, FLT3-ITD mutations), in our cohort of CN-AML patients only FLT3-ITD mutations and age represented independent factors associated with shorter OS (HR, 1.954; 95%-CI, 1.167 to 3.271; p=0.011 and HR, 1.054; 95%-CI, 1.028 to 1.081; p<0.001, respectively) (Table 2).