With the knowledge that PIM1 and CDK4/6 kinases may be effective targets in RCC, and that PIM1 kinase inhibition improves the activity of sunitinib in RCC, we hypothesized that abemaciclib (a dual PIM1-CDK4/6 inhibitor) will be an active agent in RCC and that it may improve the activity of sunitinib when used in combination. Here, CDK4 is linked to renal cell carcinoma.