Our data suggest that the targeting of both CDK4/6 and PIM1 is important for the activity of abemaciclib in RCC, as neither SGI-1776 (PIM1 inhibitor) nor palbociclib (CDK4/6 inhibitor) are as potent as abemaciclib in cell culture (see Figure 2). Here, PIM1 is linked to renal cell carcinoma.