FLT3 and acute myeloid leukemia: Beside significant enrichment for hits and pathways typically associated with AML [e.g. nucleophosmin (NPM1), fms related tyrosine kinase 3 (FLT3), NRAS proto-oncogene GTPase (NRAS)], we also found a notable number of hits in pathways associated with response to DNA damage as well as apoptosis and cell survival [e.g. mutS homolog 2 (MSH2), forkhead box O3 (FOXO3), cell division cycle 27 (CDC27)] (Supplementary Table 5).