Notably, the top 1000 most significant genes of this signature were significantly enriched for members of pathways associated with cancer [e.g. ABL proto-oncogene1 (ABL1), mutS homolog 6 (MSH6), nucleoporin 98 (NUP98), tumor protein 53 binding protein 2 (TP53BP2)] and DNA repair [e.g. breast cancer 1 (BRCA1), MSH6, TP53BP2, small ubiquitin-like modifier 1 (SUMO1)] as well as apoptosis following DNA damage [e.g. protein tyrosine phosphatase non-receptor type 12 (PTPN12), nuclear factor kappa B subunit 1 (NFKB1)] (Supplementary Table 3). This evidence concerns the gene BRCA1 and cancer.