Based on our findings that PPP4R2 is differentially expressed in hematopoiesis and leukemia as well as its involvement in DDR (Figure 5), we aimed to investigate whether our hypothesis that deregulated DNA repair promoted by PPP4R2 depletion may contribute to leukemia development is also reflected by global gene expression data of primary AML samples. Here, PPP4R2 is linked to acute myeloid leukemia.