To determine effects of Ppp4r2 loss-of-function in a leukemic state, Ppp4r2 knockdown experiments were carried out in murine myeloid/lymphoid or mixed-lineage leukemia translocated to 3 -lysine methyltransferase 2A (MLLT3-KMT2A, formerly known as MLL-AF9) transformed Lin- BM cells, which fully recapitulate human myeloid KMT2A leukemia [30–32]. Here, PPP4R2 is linked to leukemia.