Knockdown of Ppp4r2 in murine MLLT3-KMT2A leukemia followed by induction of DSB was further accompanied by elevated levels of pRPA2, which is a specific and relevant substrate of the PPP4R2-containing PPP4 complex that impaired HR-mediated DSB repair by inefficient DDR [25]. The gene discussed is PPP4C; the disease is leukemia.