APOE and Mental deterioration: found that the effect of atrophy slowing with age in AD was stronger in APOE e4 noncarriers than carriers in the entorhinal cortex; this corroborates the finding by Na et al., of faster cognitive decline in early-onset atypical AD cases, which trended toward absence of an APOE e4 allele (Holland et al., 2013, Na et al., 2016).