AD patients had the highest atrophy rates of 14 mL/y (95% CI: 12.94–15.12), for the whole brain and 0.2 mL/y (0.16–0.20) for the hippocampus, MCI followed with rates of 10 mL/y (9.17–10.70) for the whole brain and 0.1 mL/y (0.11–0.14) for the hippocampus, for APOE negative individuals with the mean age, TIV and WMH load. The gene discussed is APOE; the disease is Alzheimer disease.