CHD1L and hepatocellular carcinoma: Human ALC1 (Amplified in liver cancer 1), also known as CHD1L (Chromodomain-helicase-DNA-binding protein 1-like), is a remodeler encoded by a gene located within human chromosome 1q21, a region that is frequently amplified in hepatocellular carcinomas (Ma et al., 2008, Marchio et al., 1997, Wong et al., 2003).