The advances in allergy research in recent times have given rise to accumulation of significant amount of data on experimental validation of allergens as well as on molecular features like IgE-binding epitopes, IgE cross-reactivity, IgE antibodies, etc. Thorough study of these attributes is necessary to gain further understanding of allergic reactions, allergens as well as to develop strategies for prevention and treatment of allergies. This evidence concerns the gene IGHE and allergic disease.