Among those are several gene sets related to H3K27 methylation that is induced by HOTAIR through recruitment of PRC2. In addition, a gene set containing genes down regulated in non-metastasized breast cancer—and thus up regulated in metastasized breast cancer—as well as a gene set related to genes involved in epithelial to mesenchymal transition confirms the experimentally validated association between HOTAIR and breast cancer metastasis (36,37). The gene discussed is HOTAIR; the disease is breast cancer.