HCRTR2 and narcolepsy: To further analyze potential differences in anti-HCRTR2 autoantibody concentrations between narcolepsy patients and controls, the MFIAF555 index used to quantify anti-HCRTR2 autoantibodies for each subject was calculated as follows: MFIAF555 index = 100× (ΔMFIAF555 of subject)/ (ΔMFIAF555 of positive anti-HCRTR2 antibody at 1:100 dilution) (S2, S20 and S21 Tables).