PRNP and neuroblastoma: Interestingly, however, the TetraH>G allele showed a diminished ability to transduce a toxic signal associated with the accumulation of PrPSc; when SH-SY5Y cells expressing this allele were co-cultivated in the presence of chronically infected N2a neuroblastoma cells they showed a lower tendency to undergo apoptosis than their wt PrP-expressing counterparts (S3 Fig).