In accord with the concept of altered toxic behaviour, diffuse PrP deposition observed in TgPrP(H95G) mice differed from the synaptic pattern seen in scrapie infected wt mice and, in contrast to TgPrP(TetraH>G) mice, more closely resembling genetic human prion diseases arising from point mutations in the C-terminal domain [71]. This evidence concerns the gene PRNP and scrapie.