TP53 and cancer: Other genes commonly coamplified within the 12q13-15 amplicon include HMG2A, encoding an architectural transcription factor shown to be capable of cellular transformation, and TSPAN31, a gene of currently unknown function that has been shown to be amplified in multiple STS subtypes.9,10YEATS4 and CPM are genes commonly coamplified within 12q13-15 that have been implicated in dedifferentiation.11,12 YEATS4 is a putative transcription factor required for physiologic suppression of p53 function and is implicated in oncogenesis across a number of cancers.