Aurora kinase A (AURKA) is a critical mediator of mitosis that is commonly overexpressed in STS.11 Alisertib, an inhibitor of AURKA, exhibits in vitro antiproliferative effects against LPS cells73 and was associated with a 73% 12-week progression-free rate in 12 patients with LPS treated within a phase II study of the drug.74 There has yet to be additional clinical development of AURKA inhibitors in LPS. The gene discussed is AURKA; the disease is telomere syndrome.