Crocin (250 and 500 μg/kg of body weight) fed mice was associated with inhibition of Ras and dose dependent decline of ERK2 expression (Fig. 6B). Our data suggest that crocin inhibits angiogenesis by suppressing VEGF via downregulating ERK2 and its downstream Ras (Fig. 6B). Similarly, thujone, a monoterpene that inhibits melanoma lung metastasis by downregulating ERK (1/2) and its downstream Ras[50]. This evidence concerns the gene MAPK1 and melanoma.