TIMP1 and metastatic neoplasm: Serum TIMP-1 level in untreated metastatic tumor bearing control mice was 553.96±21.41 pg/mL and increased with treatment of crocin after 7 days (250 μg/ kg of body weight (591.71±71.33 pg/mL), 500 μg/ kg of body weight (640.20±24.09 pg/mL) and 21 days (250 μg/ kg of body weight (654.29±23.67 pg/mL), 500 μg/ kg of body weight (693.8±35.8 pg/mL) (Fig. 6A).