Optimal mitochondrial biogenesis and OXPHOS seem also to be required for metastatic dissemination, as demonstrated upon silencing of the master regulator PPARG coactivator 1 alpha (PPARGC1A, best known as PGC-1α) in models of breast cancer146, and upon silencing of family with sequence similarity 210 member B (FAM210B) in models of ovarian cancer (resulting in PDK4 downregulation and consequent utilization of glycolytic pyruvate in the TCA cycle)147. Here, PPARGC1A is linked to ovarian carcinoma.