P2RX7 and cancer: Extracellular ATP — which dying cancer cells can release in considerable amounts only if they can mount autophagic responses before death191,192 — mediates indeed prominent immunostimulatory and chemotactic functions upon binding to purinergic receptor P2X 7 (P2RX7) and purinergic receptor P2Y2 (P2RY2), respectively, on the surface of DCs or their precursors193,194,195.