CRIPT and infection: I therefore wonder, whether the knock-down of CRIPT after infection would be expected to have more severe effects if applied earlier (also considering that there is some delay in the downregulation of CRIPT protein after shRNA and that knockdown is probably not 100%) - in the C.elegans model there is a consitutive knock-out and it leads to defects to a degree similar to that observed in the shRNA experiments (i.e. it does not seem to be much more severe).