Moreover, for tumor homing of the NP, the LyP-1 peptide binds to p32 receptors on tumor cells, tumor blood vessels and lymphatics, and tumor macrophages, whereas the iRGD and iNGR peptides initially bind to αvβ3 integrins and CD13 receptors, respectively, on the angiogenic vessels of tumors. This evidence concerns the gene PTPN22 and neoplasm.