Results show that MnSOD and Cu/ZnSOD activities were significantly elevated, in ALS IgG-treated cells compared with untreated control (102.18 ± 3.98 vs. 52.53 ± 2.27 U/mg and 556 ± 15.12 vs. 279.64 ± 3.92 U/mg, respectively, both p < 0.001). Here, SOD2 is linked to amyotrophic lateral sclerosis.