In addition, we observed a significant increase of the index of lipid peroxidation (MDA production; Figure 1B), another confirmation of our hypothesis that ALS IgG can induce oxidative stress, that was in agreement with results obtained in vivo and ex vivo from brainstem and hippocampus of hSOD1(G93A) rats (32). The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.