HMGCR and tuberculosis: For instance, in association with anti-TB drugs, statins, a family of inhibitors of HMG-CoA reductase, originally used to lower cholesterol levels in patients, drastically enhance the efficacy of first-line TB treatments in macrophages and in vivo models (Lobato et al., 2014; Parihar et al., 2014; Skerry et al., 2014).