In this study, the effects of IKur (combined with a modest block in Ito, IKr, and IKs as presented by acacetin, a compound shown to be effective in anti-AF treatment) and INa block (two potentially effective atrial-selective block on human atrial electrophysiology) were investigated in silico using multiscale models of the human atria and state-dependent block scheme. Here, INA is linked to atrial fibrillation.