In terms of SVR index, although no step-by-subgroup interactions were found between variations of the SVR index and the subgroups of BMI, AF, central-dominant, BNP, baseline RVSP, baseline LVEDV index, baseline LVESV index, and baseline MR degree, a significant difference was found in the variations of the SVR index based on the baseline fSVI (P for interaction = 0.003), and sex and age subgroups tended to have different variations of the SVR index (P for interaction = 0.051, and 0.087, respectively; Figures S2A–C). Here, NPPB is linked to atrial fibrillation.