NFE2L2 and injury: In the same study, it was shown that geraniin, an ellagitannin isolated from Phyllanthusurinaria Linnnatural which has anti-inflammatory and antioxidant actions, inhibited NF-κB activation and induced an up-regulation of Nrf2 expression that resulted in the attenuated LPS-induced acute lung injury (Zhu et al., 2017).