Moreover, RUEA extracts inhibited the expression of E-cadherin, vimentin, and Snail in Prx1 knockdown SCC15 cells for 48 h (Supplementary Figure S1), indicating that RUEA extracts may target other molecules in addition to Prx1 to inhibit cell migration and invasion in oral cancer. The gene discussed is VIM; the disease is lip and oral cavity carcinoma.