A higher number of adjusted (6 out of 13) than unadjusted (1 out of 13) levels of the LPS-stimulated markers (i.e. IFN-γ, IL-6, MCP-1, MIP-1α, MMP-2, TNF-α) as well as the LPS-stimulated inflammation index were significantly higher in MDD patients with anxious distress (Fig. 1; Table S1). Here, IL6 is linked to major depressive disorder.