Interestingly, CALR-mutated cells show the decreased expression of several epigenetic regulators (i.e., EZH2, SUZ12, DNMT1, SETD2, MLL3, ARID4A, ARID4B, SETDB2), sister chromatid cohesins (i.e., SMC1A, SMC3, RAD21, STAG2), and splicing factors (i.e., SF3B1, SRSF1, ZFR), some of which were already described as mutated or inactivated in myeloid malignancies (Fig. 4b–d)31–38. The gene discussed is SF3B1; the disease is myeloid neoplasm.