Interestingly, CALR-mutated cells show the decreased expression of several epigenetic regulators (i.e., EZH2, SUZ12, DNMT1, SETD2, MLL3, ARID4A, ARID4B, SETDB2), sister chromatid cohesins (i.e., SMC1A, SMC3, RAD21, STAG2), and splicing factors (i.e., SF3B1, SRSF1, ZFR), some of which were already described as mutated or inactivated in myeloid malignancies (Fig. 4b–d)31–38. Here, ARID4B is linked to myeloid neoplasm.