CD34 and acquired polycythemia vera: In order to identify pathways deregulated by mutant CALR proteins in hematopoietic progenitors and unveil the molecular basis underlying the different clinical features of CALR-mutated ET patients, in this study we assessed gene (GEP) and miRNA expression profiles (miEP) in CD34+ cells from CALR-mutated ET patients and JAK2V617F-positive PV and ET subjects.