Interestingly, CALR-mutated cells show the decreased expression of several epigenetic regulators (i.e., EZH2, SUZ12, DNMT1, SETD2, MLL3, ARID4A, ARID4B, SETDB2), sister chromatid cohesins (i.e., SMC1A, SMC3, RAD21, STAG2), and splicing factors (i.e., SF3B1, SRSF1, ZFR), some of which were already described as mutated or inactivated in myeloid malignancies (Fig. 4b–d)31–38. This evidence concerns the gene SMC3 and myeloid neoplasm.