TPO signaling primarily mediates megakaryocyte growth and development, and recent studies have also identified its functions in maintaining the quiescence and self-renewal of HSCs.45 It has been reported that TPO can promote HSC quiescence during adult hematopoiesis, and decreased TPO signaling is associated with marrow failure or thrombocytopenia.45 Our results suggest a beneficial role of TPO induction in promoting HSC engraftment in a mouse AA model. Here, TPO is linked to Thrombocytopenia.