Mechanistically, STAT1 mediates the resistance of DU145 cells to docetaxel through inducing the expression of clusterin that is involved in cell survival in the presence of docetaxel, blockage of STAT1 expression by siRNA decreases clusterin expression and inhibits PC cell proliferation by re-sensitizing drug-resistant tumor cells to docetaxel [38]. This evidence concerns the gene STAT1 and pachyonychia congenita.