In this study, we found that 1) miR-193a-5p is upregulated in PC tissues and cell lines, 2) miR-193a-5p promotes HO-1 expression through downregulating Bach2 level, 3) HO-1 upregulation leads to resistance of PC3 cells to docetaxel-induced apoptosis, 4) miR-193a-5p, Bach2 and HO-1 constitute a regulatory axis and coordinate docetaxel-induced apoptosis in PC3 cells, and 5) Silencing of miR-193a-5p enhances sensitization of PC3 cells to docetaxel-induced apoptosis and reduces PC xenograft growth in vivo. The gene discussed is BACH2; the disease is pachyonychia congenita.