Similar to several other ALS/FTD related proteins (e.g. transactive response DNA-binding protein 43 (TDP-43), fused in sarcoma (FUS) and heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1)), TIA1 is an RNA binding protein that contains a C-terminal, prion-like, low complexity domain (LCD) which promotes its self-assembly and the formation of membrane-less organelles through the process of liquid-liquid phase separation (LLPS) [16, 22, 31]. Here, HNRNPA1 is linked to amyotrophic lateral sclerosis.