It is intriguing that another founder mutation affecting the LCD of TIA1 (E384K) was previously identified in Swedish and Finnish populations to cause WDM, which is characterized by late-onset slowly progressive weakness of hand and distal leg muscles and is associated with a rimmed vacuolar myopathy which is TDP-ir [10, 15]. The gene discussed is TIA1; the disease is distal myopathy, Welander type.