The main focus of this study was to elucidate the role of the uPAR-FPR1 cross-talk in sustaining melanoma cell ability to invade extracellular matrix and cross endothelial barriers, focusing on the function of the uPAR84–95 sequence which we and others have previously reported to signal trough FPR1 [21, 22, 31]. This evidence concerns the gene FPR1 and melanoma.