Only one study [86] reported on SHBG levels modification in PCOS women using a combination of EE 35 μg/NGM 250 μg and, in this study, SHBG changed from 32 nmol/l to 180 nmol/l, an increase of 148 nmol/l (p < 0.001) after 6 months of use. This evidence concerns the gene SHBG and polycystic ovary syndrome.