SHBG and neoplasm: The reasons to choose COCs are sustained by several pharmacological benefits: a decrease in LH pulsatile secretion, a reduction in total and free circulating testosterone, an inhibition of 5 α-reductase enzyme activity, an increase in sex-hormone binding globulin (SHBG) levels, diminishing free testosterone levels (fT), an increase in insulin muscle sensitivity, menses regulation, elimination of the clinical signs of hyperandrogenism, and protection of the endometrium against neoplasms [3, 10].