CCR5 and neoplasm: H&E staining of tumor thin sections revealed that both MDA-MB-231.CCR5+/+ and MDA-MB-231.CCR5−/− tumors were high grade adenocarcinomas with nuclear pleomorphism, high mitotic count (mitotic index for MDA-MB-231-CCR5+/+ tumors = 9 ± SEM 2; mitotic index for MDA-MB-231.CCR5−/− tumors = 6 ± SEM 6) and low tubule formation (Fig. 5c, d).When tumors were harvested at onset, then cultured ex vivo, MDA-MB-231.CCR5+/+ cells had a higher rate of glucose uptake and GLUT-1 expression compared to MDA-MB-231.CCR5−/− cells.