ACO1 and cancer: In addition to IDH1/2, ACO1, and TYMS, thioredoxin-domain containing antioxidant enzymes thioredoxin (TXN) and glutaredoxin 3 (GLRX3), along with catalase (CAT), peroxiredoxin 1 and 3 (PRDX1/PRDX3), were identified as candidate cancer-associated RBPs (Supplementary Figure 3), providing a potentially interesting link between antioxidant metabolism, RNA binding and cancer.