IFIH1 and infection: The HSV-1 version of the protein is a deamidase and may increase cell permissivity to infection through interactions with TNF receptor associated factor 6 (TRAF6), melanoma differentiation-associated protein 5 (MDA5), and retinoic acid-inducible gene I (RIG-I); although residues associated with deamidation and TRAF6 binding are not conserved across the neuroinvasive herpesviridae [44,45].