PPARA and metabolic dysfunction-associated steatotic liver disease: The network is hierarchically organized on multiple levels: on top lays the upstream regulator, in this case PPARC1A that regulates PPARα and NCOA on the second level (both part of PPAR signaling pathway with established roles in NAFLD[22, 23]); the third layer is represented by a series of ligand receptors or transcription factors (TFs) regulated by PPARα and NCOA, and the last row represents the selection of genes from our data set.