In those studies we identified 17 germline SNVs in the CDKN2A 5’UTR in melanoma patients during routine CDKN2A screening performed in several European countries [16] and found that approximately half of them could potentially impact on p16 INK4a post transcriptional regulation, demonstrating that some of them could disrupt IRES activity and influence the translational activity of p16 INK4a. The gene discussed is CDKN2A; the disease is melanoma.