SQSTM1 and neuroblastoma: On the other hand, in neuroblastoma SK-N-BE cells, E2 (1nM) treatment enhances the amount of LC3II protein since 4h after the stimulation (Fig 3B) without a parallel reduction of p62 protein (Fig 3B’), indicating that E2 leads to the accumulation of autophagosome without any completion of the autophagic flux.