Differing from the mechanism of anti-rheumatic drugs, ACEIs and ARBs could antagonize the actions of angiotensin II, a peptide that plays significant role in the pathogenesis of hypertension, renal disease and CVD by exerting a pro-inflammatory effect via angiotensin II type 1 receptor (AT1R)[33]. This evidence concerns the gene AGTR1 and Hypertension.