Myocardial infarction induced significant increases in the expression of MEK-1, phopho-MEK1, MAP Kinas phosphatase-3 (MKP3) and also phospho-p38 in the non-infarcted, remote myocardium of hearts subjected to LAD ligation, compared to the myocardium of non-MI mice from both WT and AKO controls (P<0.01, Fig 1), but this increase in MEK1 activation did not result in a significant change in downstream ERK1/2 phosphorylation. This evidence concerns the gene DUSP6 and myocardial infarction.