In the CRC cell line SW480 (derived from the primary tumour), Bmal1 downregulation by shRNA lead to an increase of cells in S-phase and a decrease of cells in G1-phase resembling the cell-cycle phenotype observed in the metastasis-derived cell line SW620, in which Bmal1 was already downregulated independent of the shRNA. This evidence concerns the gene BMAL1 and colorectal carcinoma.