DYRK1A and memory impairment: We have previously demonstrated the neuroprotective effects of the DYRK1A inhibitor L41 (IC50=10–60 nM) on Aβ25-35-induced toxicity in mouse brains, notably preventing the onset of memory impairments and of oxidative stress, both in terms of ROS accumulation and increased peroxidised lipids (Naert et al., 2015).